******************************************************************* * Genome-wide Complex Trait Analysis (GCTA) * version 1.25.2 * (C) 2010-2013 Jian Yang, Hong Lee, Michael Goddard and Peter Visscher * The University of Queensland * MIT License ******************************************************************* Analysis started: Mon Aug 13 18:47:42 2018 Options: --mlma --bfile /home/mw489/Somo/AllChrom_TZ --keep /home/mw489/Somo/keeplist.txt --maf 0.05 --pheno /home/mw489/Somo/blups.txt --grm-bin /home/mw489/Somo/Kinship_TZ --out /home/mw489/Somo/MCMDS_PYT_UKIRIGURU_TARI_81318 --thread-num 72 Note: the program will be running on 72 threads. Reading PLINK FAM file from [/home/mw489/Somo/AllChrom_TZ.fam]. 1344 individuals to be included from [/home/mw489/Somo/AllChrom_TZ.fam]. 86 individuals are kept from [/home/mw489/Somo/keeplist.txt]. Reading PLINK BIM file from [/home/mw489/Somo/AllChrom_TZ.bim]. 165816 SNPs to be included from [/home/mw489/Somo/AllChrom_TZ.bim]. Reading PLINK BED file from [/home/mw489/Somo/AllChrom_TZ.bed] in SNP-major format ... Genotype data for 86 individuals and 165816 SNPs to be included from [/home/mw489/Somo/AllChrom_TZ.bed]. Calculating allele frequencies ... Filtering SNPs with MAF > 0.05 ... After filtering SNPs with MAF > 0.05, there are 82515 SNPs (83301 SNPs with MAF < 0.05). Reading phenotypes from [/home/mw489/Somo/blups.txt]. Non-missing phenotypes of 86 individuals are included from [/home/mw489/Somo/blups.txt]. Reading IDs of the GRM from [/home/mw489/Somo/Kinship_TZ.grm.id]. 1344 IDs read from [/home/mw489/Somo/Kinship_TZ.grm.id]. Reading the GRM from [/home/mw489/Somo/Kinship_TZ.grm.bin]. Pairwise genetic relationships between 1344 individuals are included from [/home/mw489/Somo/Kinship_TZ.grm.bin]. 86 individuals are in common in these files. Performing MLM association analyses (including the candidate SNP) ... Performing REML analysis ... (Note: may take hours depending on sample size). 86 observations, 1 fixed effect(s), and 2 variance component(s)(including residual variance). Calculating prior values of variance components by EM-REML ... Updated prior values: 0.0246593 0.0190018 logL: 96.6028 Running AI-REML algorithm ... Iter. logL V(G) V(e) 1 98.26 0.04067 0.00000 (1 component(s) constrained) 2 109.22 0.04519 0.00000 (1 component(s) constrained) 3 109.08 0.04918 0.00000 (1 component(s) constrained) 4 108.66 0.05979 0.00000 (1 component(s) constrained) 5 106.72 0.06258 0.00000 (1 component(s) constrained) 6 106.10 0.06271 0.00000 (1 component(s) constrained) 7 106.07 0.06271 0.00000 (1 component(s) constrained) 8 106.07 0.06271 0.00000 (1 component(s) constrained) Log-likelihood ratio converged. Running association tests for 82515 SNPs ... Saving the results of the mixed linear model association analyses of 82515 SNPs to [/home/mw489/Somo/MCMDS_PYT_UKIRIGURU_TARI_81318.mlma] ... Analysis finished: Mon Aug 13 18:47:45 2018 Computational time: 0:0:3